Masu bincike na Dutsen Sinai sun gano yuwuwar manufa ta magani a cikin nau'ikan ciwon daji
Masu bincike na Dutsen Sinai sun gano yuwuwar manufa ta magani a cikin nau'ikan ciwon daji
Anonim

Masu bincike daga Makarantar Magunguna ta Dutsen Sinai, tare da haɗin gwiwar masu bincike na Cibiyar Kiwon Lafiyar Jama'a da Nazarin Kiwon Lafiyar Jama'a (INSERM) ta Faransa karkashin jagorancin Nicolae Ghinea, PhD, sun sami hanyar haɗin gwiwa tsakanin nau'in ciwon daji da yawa a cikin kowane nau'i na ciwon daji. Wannan ci gaban na iya a ƙarshe ya samar da sabuwar hanyar bincike ko magani don gano kansa da wuri ko dakatar da ci gaban ƙari. An buga binciken a cikin fitowar Oktoba 21 na New England Journal of Medicine.

Tawagar ta gano cewa ana samun mai karɓar maganin hormone da aka saba samu a cikin gabobin haihuwa na ɗan adam kuma a cikin sel na jini a cikin nau'ikan ƙari iri-iri. Masu karɓa ba su kasance a kan tasoshin jini na kowane kyallen takarda na al'ada ban da gabobin haihuwa, inda suke cikin ƙananan ƙididdiga fiye da ciwace-ciwacen daji.

"Za a iya amfani da wannan sabon alamar ƙwayar cuta don inganta gano cutar daji. Ana iya yin allurar rigakafin ciwon daji da ke daure da sabon alamar a cikin vasculature kuma zai iya bayyana ciwace-ciwacen daji a ko'ina cikin jiki ta hanyar amfani da hoton maganadisu, positron emission tomography, ko duban dan tayi. Hoto, "in ji marubucin binciken, Aurelian Radu, PhD, Mataimakin Farfesa na Ci gaba da Biology Regenerative, Makarantar Magunguna ta Dutsen Sinai.

"Za a iya samar da sabbin magunguna da za su toshe hanyoyin samar da jini na tumor, ko dai ta hanyar hana samuwar sabbin hanyoyin jini, toshe hanyoyin jini ta hanyar coagulation, ko kuma ta lalata tasoshin da ke da ciwon," in ji Dokta Radu.

Masana kimiyya sun kimanta samfuran nama daga ciwace-ciwacen mutane 1,336 a cikin nau'ikan kansar guda 11 na kowa, gami da prostate, nono, hanji, pancreatic, huhu, hanta, da ovarian. An yi amfani da su azaman gano ƙwayoyin rigakafi waɗanda ke aiki azaman na'urori masu ɗaukar hoto zuwa mai karɓar hormone, wanda ake kira Folicle-Stimulating Hormone (FSH). Ƙungiyar binciken ta gano cewa ƙwayoyin rigakafi sun samo mai karɓar FSH akan sel waɗanda ke samar da bangon tashar jini a cikin ɓangarorin ciwace-ciwacen daji, wanda ke fadada ciki da waje a kusa da ƙwayar cutar.

A cikin shirye-shiryen aikace-aikacen asibiti da nufin yin niyya ga mai karɓar FSH, ƙungiyar ta yi amfani da samfurin dabba don kimanta idan mai karɓa yana da damar yin amfani da magunguna ko magungunan warkewa da aka allura a cikin jini. A matsayin wakili na hoto, masu binciken sun yi amfani da ƙwayoyin rigakafi iri ɗaya tare da ɓangarorin gwal, waɗanda ke ba da damar ɗaukar hoto mai girma a matakin ƙananan ƙwayoyin cuta ta amfani da na'urar gani na lantarki. Nazarin ya tabbatar da cewa waɗannan nau'ikan suna taruwa akan magudanar jini a cikin ƙari amma ba sa ɗaure tasoshin jini a cikin kyallen takarda na yau da kullun.

An san kunna mai karɓar FSH don taimakawa wajen siginar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta (VEGF), furotin da ke ƙarfafa ci gaban jini, ciki har da waɗanda ke cikin ciwace-ciwacen ƙwayoyi. Don haka, toshe aikin mai karɓar FSH na iya toshe siginar VEGF.

"A halin yanzu muna binciken tsarin da ke haifar da rashin daidaituwa na FSH-receptor a kan kwayoyin da ke samar da bangon jijiyoyin jini. hanyoyin siginar ƙari, da kuma samarwa da kimantawa a cikin hotunan dabbobi da magungunan warkewa, "in ji Dokta Radu.

Idan aka kwatanta da magungunan da ake da su a halin yanzu, ana sa ran wakilai na gaba za su sami raguwar sakamako masu illa, saboda manufa ba ta nan da kusan dukkanin kyallen takarda na al'ada, kuma a cikin jini na gabobin haihuwa yana cikin ƙananan ƙananan fiye da ciwace-ciwacen daji.

Shahararren taken