Madogara daban-daban, sakamako iri ɗaya
Madogara daban-daban, sakamako iri ɗaya
Anonim

Yawancin marasa lafiya da ke fama da cututtukan hanta a halin yanzu suna samun rashin isasshen magani saboda rashin kayan aikin da aka bayar don dasawa. Koyaya, hanta da aka samu daga ƙwanƙwaran sel masu ƙarfi (iPSCs) na iya ba da madadin gaba. Masana kimiyya daga Cibiyar Max Planck na Kwayoyin Halittar Halittu da ke Berlin sun kwatanta hepatocytes daga kwayoyin halitta na mahaifa tare da hepatocytes daga kwayoyin iPS kuma sun gano cewa yanayin halittarsu yana kama da juna. Duk da haka, idan aka kwatanta da "hakikanin" hepatocytes, a ƙarƙashin rabin kwayoyin halitta sun nuna wani nau'i na nau'i daban-daban. Sabili da haka, bayanin kwayar halitta na hepatocytes da aka samo daga sel iPS har yanzu yana buƙatar daidaitawa kafin a iya amfani da kwayoyin halitta don maganin cututtukan hanta. (Stem Cells and Development, Disamba 20, 2010)

Za a iya samun ƙwanƙwalwar sel masu ƙarfi da yawa daga nau'ikan tantanin halitta daban-daban kuma suna da asali iri ɗaya da na zuriyarsu. Hepatocytes da aka samo daga iPSCs don haka ya zama wuri mai kyau na tashi don farfadowa na farfadowa na gaba, kamar yadda za a iya kauce wa ƙin yarda da rigakafi tsakanin masu bayarwa da ƙwayoyin cuta.

A cikin binciken nasu, masana kimiyya na Max Planck sun kwatanta ƙwayoyin hanta-kamar ƙwayoyin hanta waɗanda aka samo daga ƙwayoyin iPS da ƙwayoyin embryonic tare da hanta "haƙiƙa" a farkon matakan haɓakawa da kuma daga baya. Justyna Jozefczuk daga Cibiyar Max Planck don Kwayoyin Halittar Halittu ta bayyana cewa: "Hanyar ita ce kaɗai za a iya sanin ainihin bambance-bambance tsakanin nau'in tantanin halitta, da duk wani lahani da ke cikin hanta 'synthetic'". Masanan kimiyya sun iya nuna cewa bayanin kwayoyin halittar hepatocytes dangane da kwayoyin halitta na amfrayo da iPSC sun kasance kusan kashi 80 cikin dari. Koyaya, idan aka kwatanta da keɓaɓɓen sel daga hanta ɗan ɗan tayin, madaidaicin maganganun kwayoyin halitta shine kawai kashi 53 cikin ɗari.

Kwayoyin hepatocyte-kamar daga iPSCs da embryonic stem cell suna kunna yawancin sunadaran hanta na yau da kullun, misali, albumin, alpha-fetoprotein da cytokeratin 18. Bugu da ƙari, hepatocytes na "synthetic" na iya adana glycogen kuma su samar da urea, kamar yadda "hakikanin" hepatocytes.. Bugu da kari, suna iya tsotsewa da rushe kwayoyin halittu na kasashen waje. Sabanin haka, kwayoyin halittar da ke kewaye da rukunin enzyme cytochrome P450 a cikin iPSCs kuma a cikin hanta hanta suna nuna matakan magana daban-daban. Wadannan enzymes metabolize, a tsakanin sauran abubuwa, kwayoyi da na waje abubuwa. "Wannan ilimin ba wai kawai yana taimaka mana mu fahimci abubuwan da ke haifar da cututtukan hanta ba; yana kuma ba mu damar samar da ingantattun magunguna na musamman ga marasa lafiya", in ji James Adjaye daga Cibiyar Max Planck don Kwayoyin Halitta.

Shahararren taken