Kwayoyin suna magana da yawa a wuraren da cutar Alzheimer ta fara fara farawa, suna haɓaka ɓangaren plaque
Kwayoyin suna magana da yawa a wuraren da cutar Alzheimer ta fara fara farawa, suna haɓaka ɓangaren plaque
Anonim

Matsakaicin matakan tantanin halitta yana haɓaka amyloid beta a cikin sassan kwakwalwar da Alzheimer ya fara farawa, masu bincike a Makarantar Medicine na Jami'ar Washington a St. Louis rahoton. Amyloid beta shine babban sinadari na raunukan plaque da ke alamar cutar Alzheimer.

Waɗannan yankuna na kwakwalwa suna cikin hanyar sadarwar da ta fi aiki lokacin da kwakwalwa ke hutawa. Gano cewa kwayoyin halitta a wadannan yankuna suna sadarwa da juna akai-akai fiye da sel a wasu sassan kwakwalwa na iya taimakawa wajen bayyana dalilin da yasa wadannan wuraren ke yawan zama a cikin na farko don samar da allunan, a cewar masu binciken.

Yin aiki tare da berayen da aka yi amfani da kwayoyin halitta don haɓaka sauye-sauyen nau'in kwakwalwa na Alzheimer, masana kimiyya sun rage girman da adadin plaques ta hanyar rage ayyukan ƙwayoyin kwakwalwa a wasu yankuna.

Sakamakon, yana bayyana Mayu 1 a cikin Neuroscience Nature, sune sababbin don nuna alamar ƙuduri ga layin shaidun da suka nuna cewa ƙwayoyin kwakwalwa masu yawa zasu iya taimakawa da kuma hana Alzheimer's. A cewar wata sabuwar ka'ida, wace sel kwakwalwar da aka ci gaba da shagaltar da su na iya yin komai.

"Shigar da kwakwalwa a cikin ayyuka kamar karatu, zamantakewa ko karatu na iya taimakawa saboda sun rage aiki a yankuna masu saukin kamuwa da kuma kara yawan aiki a yankunan da ke da alama ba su da haɗari ga ƙaddamar da plaque na Alzheimer," in ji David M. Holtzman, MD, Andrew B. da Gretchen P. Jones Farfesa kuma shugaban Sashen Neurology. "Ina tsammanin cewa rashin barci da karuwar damuwa, wanda zai iya rinjayar hadarin Alzheimer, na iya kara yawan matakan aiki a cikin wadannan yankuna masu rauni."

Yankuna masu saukin kamuwa da kwakwalwa da aka haskaka a cikin sabon binciken suna cikin hanyar sadarwar yanayin tsoho, rukuni na yankuna na kwakwalwa waɗanda ke yin aiki sosai lokacin da kwakwalwar ba ta shiga cikin aikin fahimi. Co-marubucin Marcus Raichle, MD, farfesa a ilimin jijiya, na rediyo da kuma neurobiology, yana cikin na farko da ya bayyana tsohuwar hanyar sadarwa.

A cikin wata takarda da aka buga a shekara ta 2005, masu bincike na Jami'ar Washington sun nuna cewa yankuna a cikin hanyar sadarwa na zamani suna cikin na farko don bunkasa alamun Alzheimer. Don fahimtar dalilin da ya sa, Adam Bero, ɗalibin da ya kammala karatun digiri a dakin gwaje-gwaje na Holtzman, ya yi nazari kan sinadarai na kwakwalwar beraye. Ya gano cewa yankunan kwakwalwar linzamin kwamfuta kwatankwacin waɗanda ke cikin hanyar sadarwar yanayin ɗan adam suna da madaidaitan matakan amyloid plaque na farkon lokacin idan aka kwatanta da sauran wurare.

Bayan haka, Bero ya nuna a cikin ƙananan beraye cewa yankunan da ke da babban plaque sun haɓaka matakan amyloid beta. A cikin gwaji na uku, ya gano cewa matakan beta mafi girma na amyloid sun faru ne ta hanyar haɓaka sadarwar salula a cikin yankunan da abin ya shafa.

Don kara tabbatar da alakar da ke tsakanin samuwar plaque da sadarwar kwayar halitta, masana kimiyya sun datse barasar a gefe guda na rukunin berayen kuma suka rage tsawon wata guda.

"Saboda berayen dare ne kuma idanunsu ba su da kyau, shan ruwa wata hanya ce mai mahimmanci a gare su don gane inda suke a cikin muhallinsu," in ji Holtzman. "Ta hanyar yanke barasa a gefe ɗaya, mun rage yawan aikin neuronal a yankin kwakwalwa wanda ke jin motsin whisker."

Asarar wannan shigarwar ya haifar da ƙarami kuma ƙasa da yawa a gefen kwakwalwar da ke da alaƙa da tsinken barasa. A cikin wani gwaji na daban, lokacin da masu bincike ke motsa barasa akai-akai tare da swab auduga, matakan amyloid beta sun karu.

A cewar Holtzman, sakamakon ya nuna alaƙa kai tsaye tsakanin samuwar amyloid plaque samuwar da girma da kuma canje-canje a matakan ayyukan ƙwayoyin ƙwayoyin cuta a sassa daban-daban na kwakwalwa. Ya shirya ƙarin bincike na hanyoyin da ke daidaita ayyukan kwakwalwar da ba ta dace ba, alaƙarsu da abubuwan al'amura kamar barci, da kuma tasirin su akan cutar Alzheimer.

Shahararren taken