Vitamin E yana taimakawa rage nau'in cutar hanta mai kitse a wasu yara
Vitamin E yana taimakawa rage nau'in cutar hanta mai kitse a wasu yara
Anonim

Wani nau'i na bitamin E ya inganta mafi tsananin nau'in cutar hanta mai kitse a cikin wasu yara, bisa ga wani bincike da Cibiyar Kiwon Lafiya ta Kasa ta bayar. Sakamako sun bayyana a cikin fitowar Afrilu 27 na Journal of the American Medical Association. Wani bincike da aka yi a baya ya gano cewa bitamin E yana da tasiri a wasu manya masu fama da cutar.

Cutar hanta mai ƙiba (NAFLD) ita ce mafi yawan cututtukan hanta na yau da kullun tsakanin yaran Amurka. NAFLD ya bambanta da tsanani daga steatosis (mai a cikin hanta ba tare da rauni ba) zuwa steatohepatitis mara barasa ko NASH (mai, kumburi, da lalacewar hanta). Hanta mai kitse yana ƙara haɗarin yaro na kamuwa da cututtukan zuciya da hanta cirrhosis. Hanya daya tilo da za a iya bambanta NASH daga sauran nau'ikan cututtukan hanta mai kitse ita ce ta hanyar biopsy hanta. Rage nauyi na iya sauya cutar a wasu yara, amma ban da shawarar abinci, babu takamaiman jiyya. An yi imani da cewa kitse mai yawa a cikin hanta yana haifar da rauni ta hanyar haɓaka matakan oxidants, mahadi masu lalata sel.

Yawancin yara masu ciwon hanta masu kiba suna da kiba kuma suna jure wa insulin, wani muhimmin hormone mai daidaita kuzari. Yaran maza sun fi fuskantar matsalar fiye da 'yan mata, kamar yadda yara 'yan Hispanci suke idan aka kwatanta da Amurkawa da turawa.

Ta hanyar amfani da biopsies na hanta, masu bincike sun gano cewa bayan makonni 96 na jiyya, kashi 58 cikin dari na yaran da ke dauke da bitamin E ba su da NASH, idan aka kwatanta da kashi 41 cikin dari na yara a kan metformin (maganin ciwon sukari), da kashi 28 a kan placebo. Vitamin E ya fi placebo kyau saboda yana rage girman girma da mutuwar ƙwayoyin hanta.

"Wadannan sakamakon sun nuna cewa bitamin E yana inganta ko magance NASH a cikin akalla rabin yara, wanda a baya mun nuna gaskiya ne a cikin manya," in ji Stephen P. James, MD, darektan cututtuka na narkewa da abinci mai gina jiki a NIH's National Institute of Ciwon sukari da Ciwon Jiki da Cututtukan koda (NIDDK), wadanda suka dauki nauyin binciken. Yayin da sakamakon yana ƙarfafawa, marasa lafiya da ke amfani da bitamin E don NASH ya kamata su kasance ƙarƙashin kulawar likita. "Muna fatan ginawa a kan waɗannan sakamakon ta hanyar neman wasu hanyoyin kwantar da hankali da kuma dogara, hanyoyin da ba su da tasiri don kula da cutar da kuma mayar da martani ga farfadowa."

Jiyya na Cutar Hanta mai Fatty A cikin Yara (TONIC) gwaji yayi nazari akan ko bitamin E (antioxidant) ko metformin na iya inganta cututtukan hanta mai kitse. Ƙarshen don auna nasara shine ko dai ci gaba da raguwa a cikin hanta enzyme alanine aminotransferase (ALT) ko inganta hanta kamar yadda biopsies ya nuna. Adadin yara 173, akasarinsu farare da ƴan ƙasar Hispaniya masu shekaru 8 zuwa 17, an ɗauke su zuwa ƙungiyoyin jiyya guda uku. Yaran sun karɓi ko dai milligram 500 na metformin ko raka'a 400 na duniya na nau'in halitta na bitamin E ko placebo sau biyu a rana har tsawon shekaru biyu.

Babu bitamin E ko metformin da suka kasance mafi mahimmanci fiye da placebo wajen rage matakan ALT. Kashi ashirin da shida cikin dari na marasa lafiya akan bitamin E, kashi 16 akan metformin, da kashi 17 cikin dari na waɗanda ke kan placebo sun rage matakan enzyme hanta. Abin sha'awa, matakan ALT sun inganta da sauri a tsakanin marasa lafiya a kan bitamin E (a cikin watanni shida) idan aka kwatanta da wadanda ke kan placebo. Matakan ALT tsakanin yaran da ke kan placebo sun inganta cikin shekaru biyu.

"Mun yi imanin cewa duk yaran da ke cikin gwaji sun amfana daga yawan abinci da shawarwarin motsa jiki da aka bayar a duk lokacin binciken," in ji Joel E. Lavine, MD, Ph.D., babban mai bincike na TONIC da farfesa a fannin ilimin yara a Jami'ar Columbia, New York. "Yanzu muna da bayanai game da tarihin halitta na ƙungiyar placebo a tsawon lokaci, wanda zai taimaka mana wajen tsara gwaji na gaba."

Yin amfani da biopsies a cikin yara masu ciwon hanta na musamman ne. "TONIC yana raguwa a bangarorin biyu. Shi ne binciken farko da aka yi amfani da kwayar cutar hanta don kimanta yiwuwar jiyya ga kowace cutar hanta a cikin yara, "in ji Patricia Robuck, Ph.D., MPPH., masanin kimiyyar aikin a NIDDK. "Har ila yau, shine farkon cibiyar da yawa, bazuwar, gwajin gwaji don amfani da hanta biopsy don kimanta maganin hanta mai hanta a cikin yara, wanda aka yi la'akari da mafi kyawun zane don nazarin cututtukan hanta."

TONIC an gudanar da shi ta hanyar NASH Clinical Research Network masu binciken a:

* Case Western Reserve University da Cleveland Clinic, Cleveland

* Cibiyar Kula da Lafiya ta Yara, Washington, D.C.

* Jami'ar Indiana, Indianapolis

* Jami'ar Johns Hopkins, Baltimore (cibiyar daidaita bayanai)

* Jami'ar Saint Louis da Jami'ar Washington, St. Louis

* Asibitin Yara na Texas, Houston

* Jami'ar California, San Diego

* Jami'ar San Francisco

* Jami'ar Commonwealth ta Virginia, Richmond

* Cibiyar Kiwon Lafiya ta Virginia Mason, tare da Jami'ar Washington, Seattle

Ƙarin tallafi na NIH ga TONIC an ba da shi ta Cibiyar Ciwon daji ta Ƙasa, Cibiyar Harkokin Kiwon Lafiyar Jama'a ta Ƙasa Eunice Kennedy Shriver, da Cibiyar Nazarin Kasa ta Kasa. Ƙara koyo game da TONIC a www.clinicaltrials.gov (bincika NCT00063635) da kuma game da cibiyar sadarwar NASH a

NIDDK, wani ɓangare na NIH, yana gudanar da tallafawa bincike kan ciwon sukari da sauran cututtukan endocrine da na rayuwa; cututtuka na narkewa, abinci mai gina jiki da kiba; da koda, urologic da hematologic cututtuka. Dangane da cikakken nau'in magani da cutar da mutane na kowane zamani da kabilanci, waɗannan cututtukan sun haɗa da wasu yanayi na yau da kullun, masu tsanani da nakasa da ke damun Amurkawa. Don ƙarin bayani game da NIDDK da shirye-shiryenta, duba www.niddk.nih.gov.

Game da Cibiyoyin Lafiya na Ƙasa (NIH): NIH, hukumar binciken likitancin kasar, ta hada da Cibiyoyi da Cibiyoyi 27 kuma wani bangare ne na Ma'aikatar Lafiya da Ayyukan Jama'a ta Amurka. NIH ita ce hukumar tarayya ta farko da ke gudanarwa da tallafawa bincike na likita na asali, na asibiti, da na fassara, kuma tana binciken musabbabi, jiyya, da kuma warkar da cututtuka na gama gari da na yau da kullun. Don ƙarin bayani game da NIH da shirye-shiryenta, ziyarci www.nih.gov.

Shahararren taken