Cire 'alkyabba' ga nanoparticles taimaka musu hari ciwace-ciwacen daji
Cire 'alkyabba' ga nanoparticles taimaka musu hari ciwace-ciwacen daji
Anonim

Injiniyoyin sinadarai na MIT sun ƙirƙira wani sabon nau'in nanoparticle na isar da ƙwayoyi wanda ke yin amfani da yanayin da kusan dukkanin ciwace-ciwacen daji ke rabawa: Sun fi acidic kyawu.

Irin wannan barbashi na iya kaiwa kusan kowane nau'in ciwon daji, kuma ana iya ƙera su don ɗaukar kusan kowane nau'in magani, in ji Paula Hammond, memba na Cibiyar Nazarin Ciwon Ciwon Kankara ta David H. Koch a MIT kuma babban marubucin wata takarda da ke kwatanta barbashi. a cikin mujallar ACS Nano.

Kamar yawancin nau'ikan nanoparticles masu isar da ƙwayoyi, sabbin ƙwayoyin MIT an lulluɓe su a cikin wani yanki na polymer wanda ke kare su daga lalatawar jini. Koyaya, ƙungiyar MIT, ciki har da marubucin jagora kuma abokiyar karatun digiri na biyu Zhyong Poon, sun tsara wannan Layer na waje don faɗuwa bayan shigar da yanayin ɗan ƙaramin acid kusa da ƙari. Wannan yana bayyana wani Layer wanda zai iya shiga kowane ƙwayoyin ƙwayar cuta.

A cikin takarda ACS Nano, wanda ya shiga kan layi a ranar 23 ga Afrilu, masu binciken sun ba da rahoton cewa, a cikin berayen, barbashin su na iya rayuwa a cikin jini har zuwa sa'o'i 24, suna taruwa a wuraren ciwon daji kuma su shiga ƙwayoyin tumor.

Sabuwar manufa

Sabuwar hanyar MIT ta bambanta da wanda yawancin masu ƙirar nanoparticle suka ɗauka. Yawanci, masu bincike suna ƙoƙari su kai hari ga barbashi zuwa wani ƙari ta hanyar yi musu ado da kwayoyin halitta waɗanda ke ɗaure musamman ga sunadaran da aka samu a saman ƙwayoyin cutar kansa. Matsalar wannan dabarar ita ce, yana da wuya a sami maƙasudin da ya dace - kwayar halitta da aka samo akan dukkan ƙwayoyin cutar kansa a cikin wani ƙwayar cuta, amma ba akan ƙwayoyin lafiya ba. Har ila yau, makasudin da ke aiki ga nau'in ciwon daji guda ɗaya bazai yi aiki ga wani ba.

Hammond da abokan aikinta sun yanke shawarar yin amfani da acidity na tumor, wanda ya samo asali ne daga farfadowar metabolism. Kwayoyin Tumor suna girma da rarraba da sauri fiye da sel na al'ada, kuma wannan aikin na rayuwa yana amfani da iskar oxygen mai yawa, wanda ke ƙara yawan acidity. Yayin da ƙari ke girma, nama yana ƙara ƙara acidic.

Don gina ɓangarorin da aka yi niyya, masu binciken sun yi amfani da wata dabara da ake kira “Layer-by-Layer Assembly.” Wannan yana nufin kowane Layer ana iya keɓance shi don yin takamaiman aiki.

Lokacin da Layer na waje (wanda aka yi da polyethylene glycol, ko PEG) ya rushe a cikin yanayin acidic na tumor, an bayyana wani Layer na tsakiya mai inganci. Wannan tabbataccen cajin yana taimakawa wajen shawo kan wani cikas ga isar da magungunan nanoparticle: Da zarar ɓangarorin sun isa ƙari, yana da wahala a sa su shiga sel. Barbashi tare da tabbataccen caji na iya shiga cikin ƙwayar ƙwayar ƙwayar cuta mara kyau, amma irin wannan barbashi ba za a iya allura a cikin jiki ba tare da "alkyabba" na wani nau'i ba saboda suna lalata kyallen takarda.

Layer na ciki na nanoparticles na iya zama polymer mai ɗauke da maganin cutar kansa, ko ɗigon ƙima wanda za a iya amfani da shi don yin hoto, ko kusan duk wani abu da mai zanen zai so ya isar, in ji Hammond, wanda Farfesa ne na Injiniyan Kimiyya na Bayer a MIT.

Layer ta Layer

Sauran masu bincike sun yi ƙoƙarin tsara nanoparticles waɗanda ke cin gajiyar acidity na ciwace-ciwacen daji, amma ƙwayoyin Hammond sune farkon waɗanda aka yi nasarar gwadawa a cikin dabbobi masu rai.

Jinming Gao, farfesa a fannin ilimin likitanci da ilimin harhada magunguna a Jami'ar Texas Southwestern Medical Center, ya ce "yana da wayo sosai" a yi amfani da taron Layer-by-Layer don ƙirƙirar barbashi tare da Layer na kariya wanda za'a iya zubar lokacin da barbashi ya kai ga abin da suke so. Gao, wanda ba ya cikin ƙungiyar masu binciken ya ce: "Kyakkyawan hujja ce ta ra'ayi." "Wannan na iya zama wata dabara ta gabaɗaya don kai hari ga microenvironment na ƙwayar ƙwayar cuta don ingantacciyar isar da magunguna."

Masu binciken suna shirin kara haɓaka waɗannan barbashi da gwada ikon su na isar da magunguna a cikin dabbobi. Hammond ta ce tana tsammanin zai iya ɗaukar shekaru biyar zuwa 10 na ci gaba kafin a fara gwajin lafiyar ɗan adam.

Hakanan ƙungiyar Hammond tana aiki akan nanoparticles waɗanda zasu iya ɗaukar kaya masu yawa. Misali, layin PEG na waje na iya ɗaukar magani ko kwayar halitta wanda zai “fifi” ƙwayoyin ƙari don zama masu saurin kamuwa da wani magani da aka ɗauka a cikin ɓangarorin.

Shahararren taken