Fasahar kyamarar gidan yanar gizo da ake amfani da ita don auna tasirin magunguna akan zuciya
Fasahar kyamarar gidan yanar gizo da ake amfani da ita don auna tasirin magunguna akan zuciya
Anonim

Wani sashe na gama gari a cikin kyamarar gidan yanar gizo na iya taimakawa masu yin magunguna da masu rubutawa su magance wani sakamako na gaba ɗaya na magungunan da ake kira cardiotoxicity, canji mara kyau a yadda zuciya ke bugun. Masu bincike a Brigham da Asibitin Mata (BWH) sun yi amfani da ainihin fasahar kyamarar gidan yanar gizon don ƙirƙirar kayan aiki don duba tasirin magunguna a ainihin lokacin akan ƙwayoyin zuciya, wanda ake kira cardiomyocytes. An buga waɗannan binciken a cikin mujallar, Lab on a Chip ranar 11 ga Afrilu, 2011.

Masu bincike sun ɓullo da ingantaccen farashi, mai ɗaukar hoto na tushen kwayar halitta don gano cututtukan zuciya na ainihin lokacin ta amfani da firikwensin hoto daga kyamarar gidan yanar gizo. Sun ɗauki cardiomyocytes, waɗanda aka samo daga ƙwayoyin linzamin kwamfuta, kuma sun gabatar da sel zuwa magunguna daban-daban. Yin amfani da biosensor, masu binciken sun sami damar saka idanu kan yawan bugun jini na cardiomyocytes a cikin ainihin lokaci kuma suna gano duk wani canje-canjen da miyagun ƙwayoyi ya haifar a cikin ƙimar bugun.

Fasaha tana ba da hanya mai sauƙi don yin nazarin kimantawa na tasirin magunguna daban-daban akan ƙwayoyin zuciya. Cardiotoxicity babbar matsala ce a ci gaban ƙwayoyi, tare da sama da kashi 30 na magungunan da aka janye daga kasuwa tsakanin 1996 zuwa 2006 masu alaƙa da tabarbarewar zuciya. Ali Khademhosseini, PhD, na Cibiyar Injiniya ta Biomedical ya ce "Yin la'akari da illolin da sabbin magunguna ke haifarwa a farkon matakan haɓaka magunguna na iya haɓaka tsarin gano magungunan, wanda ke haifar da tsada mai yawa da tanadin lokaci, da kuma haifar da saurin gano magani," in ji Ali Khademhosseini, PhD, na Cibiyar Injiniya ta Biomedical. a Sashen Magunguna a BWH.

"Wannan fasaha kuma za ta iya taka rawa a cikin maganin da aka keɓance," in ji Sang Bok Kim, PhD, Fellow Fellow a Renal Division a BWH. "Ta hanyar fitar da ƙwayoyin somatic da farko daga marasa lafiya waɗanda za a iya sake tsara su zuwa sel mai tushe da ake kira induced pluripotent stem (iPS). Sa'an nan kuma waɗannan kwayoyin iPS za a iya bambanta su zuwa ƙwayoyin zuciya don yin nazari, biosensor na iya kula da ƙwayoyin zuciya yayin da aka gabatar da su. zuwa magani, yana ba da hangen nesa kan yadda magungunan za su iya shafar zuciyar mutum, kuma ta haka za su tsara tsarin jiyya ga mutumin."

Kula da ƙwayoyin zuciya a baya yana buƙatar amfani da kayan aiki masu tsada waɗanda ke da iyakataccen wurin aunawa. Wannan ƙananan farashi (kasa da $ 10) biosensor ya dace da kayan aiki na al'ada amma zai ba da damar ingantaccen, duk da haka sauri kuma mafi inganci karatu.

"Manufarmu ta gaba ita ce hada firikwensin ganowa tare da tsararrun microwell da kuma yin nazarin duban dubban magunguna zuwa ƙwayoyin zuciya a lokaci guda cikin sauri da aminci," in ji Dr. Khademhosseini.

Shahararren taken