Yadda Gut Bacteria ke Tasirin Kiba
Yadda Gut Bacteria ke Tasirin Kiba
Anonim

Haɗin da aka ƙirƙira tsakanin tiriliyan na ƙwayoyin cuta waɗanda ke kiran guts ɗin mu gida da yanayi kamar kiba ya ƙara zama daɗaɗa kai cikin lokaci.

Nazarin ya gano cewa cin abinci mai yawan kitse, al'adar haɗari na gama gari na kiba, na iya haifar da tartsatsi mai yaduwa ga yanayin ƙananan ƙwayoyin cuta, ko microbiota, a cikin gwajin dabbobi kamar mice da zebrafish. Wasu, a halin yanzu, sun nuna cewa wannan hanyar haɗin yanar gizon tana aiki duka biyu: Lokacin da masana kimiyya suka dasa ƙwayoyin cuta daga rukunin ɓangarorin lafiya zuwa rukunin berayen da aka ƙera don ba su da ƙwayoyin cuta kwata-kwata, berayen da ba su da ƙwayoyin cuta sun zama masu kiba. An ga irin wannan tasirin ko da lokacin da aka dasa kwayoyin cutar hanji daga masu kiba zuwa cikin wadannan berayen.

A mafi yawancin lokuta, kodayake, har yanzu muna cikin duhu sosai game da yadda wannan dangantakar ke aiki. Ba tare da fahimtar wannan muhimmin yanki na wuyar warwarewa ba, ba zai yuwu a gare mu mu taɓa yin amfani da haɗin kai don fa'idarmu don hana ko magance kiba. Wani sabon binciken linzamin kwamfuta da aka buga Laraba a cikin Nature, duk da haka, na iya haskaka inda za a duba.

Kwayoyin cuta

Ƙaƙƙarfan Fat

Babban marubuci Dokta Gerald Shulman, babban darektan cibiyar bincike kan ciwon sukari ta Yale, ya shaida wa Medical Daily cewa shi da abokan aikinsa sun gudanar da gwaje-gwaje iri-iri da nufin bin diddigin binciken linzamin kwamfuta da aka buga a shekarar da ta gabata. Wannan binciken ya sami wata alaƙa ta bambanta tsakanin juriya na insulin, haɗarin haɗari na duka nau'in ciwon sukari na 2 da kiba, da haɓaka matakan sinadarai na acetate, wanda wani ɓangare ne na ƙungiyar motley da aka sani da gajeriyar sarkar fatty acid (SCFAs). Don sabon binciken da suka yi, suna son gano yadda da kuma dalilin da ya sa hakan ya faru.

Bayan nazarin berayen masu jure wa insulin suna ciyar da abinci mai kitse har zuwa makonni huɗu, sun gano cewa waɗannan berayen suna da acetate da yawa a jikinsu fiye da ɓerayen da ke kan abinci na yau da kullun. Duk wannan acetate ya inganta haɓakar ƙwayar insulin daga pancreas (wanda ya haifar da matakan sukari mafi girma a cikin jini) da kuma ƙara yawan matakan ghrelin na yunwa. Masu binciken sun ce mai yiyuwa ne aka kunna wannan tsari ta hanyar tsarin jin tsoro na parasympathetic, wanda ya ƙunshi jijiyoyi na musamman waɗanda ke taimakawa daidaita hanyoyin jikin da ba su sani ba kamar salivating, sha'awar jima'i, da narkewa.

Tunanin cewa ƙwayoyin cuta na ƙwayoyin berayen masu kiba sun mamaye abinci kuma suka samar da acetate, sun mamaye tsarin narkewar ɓerayen - ta hanyar yanke dukkan hanjin su misali. Da zarar an yi, matakan acetate sun koma ƙasa zuwa kusa da al'ada. A cikin wasu gwaje-gwaje guda biyu, masu binciken sun kuma ga ƙwayoyin gut suna samar da acetate lokacin da aka tsara su a cikin dakin gwaje-gwaje, kuma lokacin da suka yi maganin zubar da jini daga waɗannan berayen tare da maganin rigakafi mai yawa, sun ga raguwa mai mahimmanci a samar da acetate.

Duk waɗannan gwaje-gwajen sun ba da shawarar cewa gut microbiota, wanda aka haɓaka ta hanyar abinci mai yawa, shine babban tushen samar da acetate a cikin mice, marubutan sun rubuta.

Shulman da abokan aikinsa kuma sun sami damar ƙirƙirar madaidaicin ra'ayi; ta hanyar ci gaba da cusa ɓerayen su da acetate na tsawon kwanaki 10 kai tsaye, sun mai da berayen yadda ya kamata su zama injinan ci masu kiba. A wasu kalmomi, berayen sun ɓoye ƙarin insulin da ghrelin saboda acetate, wanda hakan ya haifar da karuwar yunwa da cin abinci, kuma daga ƙarshe zuwa juriya na insulin, karuwar nauyi, da sauran matsalolin rayuwa. Duk abincin da aka ƙara kawai ya jefa ƙarin acetate a cikin tsarin, wanda ya sake fara madauki.

A cikin mutane, ana iya ganin wannan madauki ɗaya lokacin da suke ci gaba da cin abinci mai mai mai yawa - abincin a hankali yana canza yanayin microbiota na gut ɗin su don fifita ƙwayoyin cuta masu samar da acetate, wanda ke sa mutane su ci abinci mai yawa. Sa'an nan, sake zagayowar yana maimaita.

"Tare, waɗannan binciken sun gano haɓakar haɓakar acetate wanda ya haifar da hulɗar microbiota mai gina jiki da kuma kunna parasympathetic na gaba kamar yadda yiwuwar warkewa don kiba," marubutan sun rubuta.

Tabbas kiba da yanayin da ke tattare da ita matsala ce mai dimbin yawa, wacce ke haifar da hadaddun abubuwa masu sarkakiya wasu lokuta kuma masu karo da juna. Sauran SCFAs, kamar butyrate - wanda aka samar a lokacin da ƙwayoyin hanji ke narke fiber - sun nuna ikon kariya daga haɓakar kiba. Kuma yayin da aka san cin abinci mai kitse don haɓaka haɓakar nau'in ƙwayoyin cuta Firmicutes yayin da rage matakan Bacteroidates (ciki har da binciken na yanzu), har yanzu ba mu sani ba ko sake fasalin microbiotas ɗin mu zai dakatar da madauki a cikin waƙoƙinsa.. Wannan ya ce, wasu shaidun farko sun nuna cewa mutane masu kiba da aka ba su dashen fecal daga masu ba da gudummawa suna ci gaba da samun canje-canje masu kyau a cikin metabolism.

Yanzu haka dai tawagar Shulman na shirin gwada ko za a iya maimaita sakamakonta a cikin mutane.

Shahararren taken